The variables are broad, with this question, as with any supplement or drug, for that matter. Your practitioner has to take into account the number of co-infections; levels of toxins present in the body; length of illness; how compromised your immune system is; your diet, self-care habits (are you getting enough rest and managing your levels of stress?); level of Metabolic health; number of herbs, supplements, and pharmaceutical side effects; (some mimic Lyme symptoms) and more factors, that your health care provider can advise you on.